Patients & Caregivers

Science that’s focused on patients first

At CareBiom, we employ rigorous translational science to discover novel medicines for cancer patients. Our Translational Sciences team acts as the bridge between microbiome research and clinical development, innovating in both science and process to accelerate the development of cancer quality of life programs that can make a meaningful difference for patients.

What we learn from the data on microbiome and cancer treatment, we leverage to improve future cancer treatment. As a team and an organization,
we thrive on scientific challenge and strive to deliver transformational therapies for patients.

Science that’s focused on patients first

At CareBiom, we employ rigorous translational science to discover novel medicines for cancer patients. Our Translational Sciences team acts as the bridge between microbiome research and clinical development, innovating in both science and process to accelerate the development of cancer quality of life programs that can make a meaningful difference for patients.

What we learn from the data on microbiome and cancer treatment, we leverage to improve future cancer treatment. As a team and an organization,
we thrive on scientific challenge and strive to deliver transformational therapies for patients.

Care-biom-our-mission-picture

The human microbiome is an emerging target in cancer development and therapeutics. It may be directly oncogenic, through promotion of mucosal inflammation or systemic dysregulation, or may alter anticancer immunity/therapy.

Commensal Microbiome might play a role in cancer development and progression Commensal flora are found in tumor tissue, adjacent “normal” tissue and adjacent feces, urine and mucus

  • Modulation might increase treatment efficacy, reduce toxicity and prevent carcinogenesis
  • The microbiome can be modulated and exploited to improve cancer therapeutics

While research is still at an early stage, there is potential to exploit the microbiome, as modulation may increase efficacy of treatments, reduce toxicities and prevent carcinogenesis.

The microbiome has been implicated in cancer in a variety of specific ways, including being directly oncogenic, through promotion of oncogenic mucosal inflammation or systemic metabolic/immune dysregulation and through modulation of anti-cancer immunity or the efficacy of anti-cancer therapy Analysis of the metatranscriptome, or the mRNA of the microbial community, can reveal which organisms are active and which microbial genes are being expressed [32], but because of the short halflife of mRNA, represent a single time-point of gene expression that may not reflect longer-term adaptations between the host and microbiota [33]. Similarly, proteomics examines the protein content of samples such as feces, and again since protein expression is dynamic, this test gives an analysis of the expressed and functional proteins at a particular time point [34, 35].

Finally, metabolomics is the study of the metabolites found in a sample, regardless of their organism of origin (host or microbial), and can include vitamins, short-chain fatty acids, bile acids, choline derivatives or polysaccharides, among many other compounds Collectively, these tools are used to characterize microbial taxonomic and metagenomic community composition and infer or measure microbial community and aggregate host/microbial metabolism to identify disease associations and novel targets for experimental, diagnostic or therapeutic studies.

A summary of treatment side effects associated with each of the cancers

Side effect

Cancer Type

Breast CRC HNC Lung Prostate
Bone loss X X
Bowel dysfunction X X
Cardiovascular disease X X X X
Cognitive dysfunction X X X
Dermatitis X X
Dysphagia/GERD
Endocrine disruptions (infertility, metabolic syndrome, vasomotor symptoms) X
Fatigue X X X X X
Lymphedema X X
Mental health issues (anxiety, depression, body image concerns) X X X X X
Musculoskeletal pain X X
Neuropathy X X X
Oral health issues X
Pulmonary dysfunction X X X
Sexual dysfunction X X X
Sleep apnea X
Urinary dysfunction X X